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- A Sensorimotor Polyneuropathy Caused by Chronic Phenytoin Therapy
- Dong-Chul Han, Hyeon-Mi Park, Dong-Jin Shin, Yeong-Bae Lee
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Journal of The Korean Society of Clinical Toxicology 2006;4(2):128-130
DOI: https://doi.org/
Published online: December 31, 2006
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1Department of Neurology, Gil Medical Center, Gachon University of Medicine and Science
2Department of Neurology, Gil Medical Center, Gachon University of Medicine and Science
3Department of Neurology, Gil Medical Center, Gachon University of Medicine and Science
4Department of Neurology, Gil Medical Center, Gachon University of Medicine and Science
2Department of Neurology, Gil Medical Center, Gachon University of Medicine and Science
3Department of Neurology, Gil Medical Center, Gachon University of Medicine and Science
4Department of Neurology, Gil Medical Center, Gachon University of Medicine and Science
Abstract
Phenytoin has been used globally as an effective anticonvulsant. Among its adverse effects, peripheral neuropathy including polyneuropathy has sometimes been reported. We report a case of sensorimotor polyneuropathy associated with high serum level and long-term phenytoin therapy. A 29-year-old male presented with motor weakness in all extremities. He was treated with phenytoin (400 mg/day) for about eight years because of generalized tonic clonic seizure. During none conduction assessment, sensorimotor polyneuropathy was discovered.
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Korean Society of Clinical Toxicology