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HOME > J Korean Soc Clin Toxicol > Volume 15(2); 2017 > Article
Fomepizole for Ethylene Glycol or Methanol Poisoning in Children
Ha Na Min, Yoon Jung Hwang, Dong Ryul Ko, Young Seon Joo, Tae Young Kong, Min Hong Choa, In Cheol Park, Sung Phil Chung
Journal of The Korean Society of Clinical Toxicology 2017;15(2):79-85
DOI: https://doi.org/10.22537/jksct.2017.15.2.79
Published online: December 31, 2017
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1Department of Emergency Medicine, Yonsei University College of Medicine
2Department of Emergency Medicine, Yonsei University College of Medicine
3Department of Emergency Medicine, Yonsei University College of Medicine
4Department of Emergency Medicine, Yonsei University College of Medicine
5Department of Emergency Medicine, Yonsei University College of Medicine
6Department of Emergency Medicine, Yonsei University College of Medicine
7Department of Emergency Medicine, Yonsei University College of Medicine
8Department of Emergency Medicine, Yonsei University College of Medicine

Purpose: The purpose of this study is to evaluate the effectiveness and adverse effect of fomepizole in the management of acute ethylene glycol or methanol poisoning in children. Methods: Databases such as PubMed, Embase, Cochrane library, and KoreaMed were searched using terms related to fomepizole, ethylene glycol, methanol and pediatric. All studies, regardless of study design, reporting effectiveness or safety endpoints in children were included. Reference citations from identified publications were reviewed. Only reports written in English or Korean languages were included. The reference search was performed by two authors. Results: Twenty-two relevant literatures were finally included. They were one narrative review, 4 retrospective case series, and 17 case reports (19 cases). Case reports were classified as 5 fomepizole only, 8 fomepizole with other therapies, and 6 no fomepizole. All patients from the literatures were fully recovered without long term sequelae. Adverse effects of fomepizole were reported including anaphylaxis, thrombophlebitis and nystagmus. Conclusion: There are insufficient literatures regarding fomepizole treatment in children with ethylene glycol or methanol poisoning. The benefits or harms are not clearly established based on the clinical evidences. More prospective comparative studies are required in the future.

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