Skip Navigation
Skip to contents

JKSCT : Journal of The Korean Society of Clinical Toxicology

OPEN ACCESS
SEARCH
Search

Articles

Page Path
HOME > J Korean Soc Clin Toxicol > Volume 6(1); 2008 > Article
Clinical Characteristics of Acute Dichlorvos Poisoning in Korea
Mi-Jin Lee, Joon-Seok Park, Woon-Yong Kwon, Eun-Kyung Eo, Bum-Jin Oh, Sung-Woo Lee, Joo-Hyun Suh, Hyung-Keun Roh
Journal of The Korean Society of Clinical Toxicology 2008;6(1):9-15
DOI: https://doi.org/
Published online: June 30, 2008
  • 85 Views
  • 0 Download
  • 0 Crossref
  • 0 Scopus
1Department of Emergency Medicine, College of Medicine, Konyang University
2Department of Emergency Medicine, College of Medicine, Konyang University
3Department of Emergency Medicine, Seoul National University College of Medicine
4Department of Emergency Medicine, School of Medicine, Ewha Womans University
5Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine
6Department of Emergency Medicine, Korea University College of Medicine
7Department of Internal Medicine, Gachon University of Medicine and Science
8Department of Internal Medicine, Gachon University of Medicine and Science

Purpose: Dichlorvos has been in widespread use as an organophosphate (OP) insecticide compound. The purpose of this study was to access the epidemiology and clinical features of dichlorvos in Korea. Methods: This was a 38 multi-center prospective study of dichlorvos poisoning using surveys, a structural reporting system and review of hospital records from August 2005 to July 2006. A total of 54 patients with acute dichlorvos poisoning on a national basis were enrolled. We analyzed the epidemiologic characteristics and clinical manifestations of dichlorvos poisoning. In addition, the clinical features of dichlorvos poisoning were compared with others OP compounds. Results: During the study period, compounds involving pure OP poisoning were dichlorvos (22.7%), methidathion (8.4%), and phosphamidon (6.7%). In acute dichlorvos poisoning, all ingestion routes were oral. Intentional poisoning involved 74.1% of cases. The common initial complaints involved gastrointestinal (64.8%), systemic (61.1%), central or peripheral nervous system (53.7%), and respiratory symptoms (50.0%). The median arrival time to hospital after dichlorvos poisoning was 2.6 hours and mean hospitalization duration was 7.1 days. 2-PAM was administered in 35 patients in mean doses of 6.3 g/day intravenously. Atropine was administered in 30 patients with a mean dose of 62.8 mg/day (maximal 240 mg/day). Overall mortality rate for dichlorvos poisonings were 14.8% (8/54). Immediate causes for death included sudden cardiac arrest or ventricular dysrhythmias (50%), multi-organ failure (25%), acute renal failure (12.5%), and unknown causes (12.5%). Conclusion: When compared to previous reports, dichlorvos poisoning displayed relatively moderate severity. The presence of a lower GCS score, altered mental status, serious dysrhythmias, systemic shock, acute renal failure, and respiratory complications upon presentation were associated with a more serious and fatal poisoning.

Related articles

JKSCT : Journal of The Korean Society of Clinical Toxicology