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In Seek Kim 1 Article
Two Cases of Acute Renal Failure due to Rhabdomyolysis Complicating Doxylamine Succinate Intoxication
Jae Kwon Jung, Sung Ho Kim, In Seek Kim, Seon Woong Kim, Dong Wook Ju, Duk Hyun Lee, Jong Kun Kim
J Korean Soc Clin Toxicol. 2004;2(1):15-19.   Published online June 30, 2004
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Doxylamine succinate is an antihistamine used primarily as a sleep-induction. It can be gotten without a doctor's prescription in Korea, so it' s overdoses were frequently encountered. There were several reports that the overdoses of doxylamine might cause rhabdomyolysis, but few cases have been reported that it is related to acute renal failure (ARF). In cases that ARF occur, most of them are not severe enough to require hemodialysis. We experienced two cases of severe rhabdomyolysis complicating ARF after doxylamine overdose and treated with hemodialysis. Clinicians should be aware of the potentially lethal complications of rhabdomyolysis in patients who ingest doxylamine succinate and the needs for prompt intervention and careful assessment of renal function.

JKSCT : Journal of The Korean Society of Clinical Toxicology