- A Case of Colchicine Intoxication Presenting as Acute Gastroenteritis
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Ji-Yun Ahn, You-Dong Sohn, Hyuk-Sool Kwon, Hee-Chol Ahn
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J Korean Soc Clin Toxicol. 2008;6(2):138-141. Published online December 31, 2008
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 Abstract
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- A 47-year-old woman ingested about 12 mg of colchicine with suicidal intent. Colchicine, a highly poisonous alkaloid, is a commonly used treatment for gout, Bechet's disease, and familial Mediterranean fever. Despite the knowledge of its side effects, the risk of a significant overdose is under-appreciated. She suffered from acute multisystem toxicity, including gastrointestinal disorders, bone marrow suppression, alopecia, and probable pancreatitis, but she ultimately recovered with supportive therapy. We report a case of acute colchicine toxicity from a single overdose with a review of the literature.
- A one-year Follow-up Study of Patients Exposed to Chlorine Gas
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Hyuk-Sool Kwon, You-Dong Sohn, Hee-Cheol Ahn, Ji-Yun Ahn
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J Korean Soc Clin Toxicol. 2008;6(2):99-103. Published online December 31, 2008
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Abstract
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- Purpose: Chlorine gas is a common irritant that usually causes mild respiratory symptoms. One severe symptom, RADS (Reactive Airway Dysfunction Syndrome), is not well known to physicians. We analyzed the clinical features of chlorine gas exposure. Methods: We prospectively collected 25 cases of chlorine gas exposure near our emergency center on January 10th, 2007, and analyzed demographic data, event-to-ER interval, symptoms, and laboratory results based on medical records. Results: Only 2 patients out of 25 were admitted because of severe symptoms, the rest were discharged without complications. Sixty percent of them visited the ER within 12 h of exposure. The most common symptoms were chest discomfort (60%), headache (40%), nausea (40%), throat irritation (26%), and cough (32%). Two out of eight dyspnea cases showed abnormal pulmonary function, but only one case was diagnosed as RADS. Conclusion: Most symptoms after chlorine gas exposure can be treated conservatively. However, patients with chlorine exposure should be followed up long term for delayed complications.
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KSCT
Korean Society of Clinical Toxicology